Segmenting of clinically important retinal blood vessels into arteries and veins is a prerequisite for retinal vessel analysis. Such analysis can provide potential insights and bio-markers for identifying and diagnosing various retinal eye diseases. Alteration in the regularity and width of the retinal blood vessels can act as an indicator of the health of the vasculature system all over the body. It can help identify patients at high risk of developing vasculature diseases like stroke and myocardial infarction. Over the years, various Deep Learning architectures have been proposed to perform retinal vessel segmentation. Recently, attention mechanisms have been increasingly used in image segmentation tasks. The work proposes a new Deep Learning approach for artery-vein segmentation. The new approach is based on the Attention mechanism that is incorporated into the WNet Deep Learning model, and we call the model as Attention-WNet. The proposed approach has been tested on publicly available datasets such as HRF and DRIVE datasets. The proposed approach has outperformed other state-of-art models available in the literature.

It may have its roots in science fiction, but a small number of researchers are making real progress trying to create computers out of living cells. Welcome to the weird world of biocomputing. Among those leading the way are a group of scientists in Switzerland, who I went to meet. One day, they hope we could see data centres full of living servers which replicate aspects of how artificial intelligence (AI) learns - and could use a fraction of the energy of current methods. That is the vision of Dr Fred Jordan, co-founder of the FinalSpark lab I visited.

Anatomical trees play an important role in clinical diagnosis and treatment planning. Yet, accurately representing these structures poses significant challenges owing to their intricate and varied topology and geometry. Most existing methods to synthesize vasculature are rule based, and despite providing some degree of control and variation in the structures produced, they fail to capture the diversity and complexity of actual anatomical data. We developed a Recursive variational Neural Network (RvNN) that fully exploits the hierarchical organization of the vessel and learns a low-dimensional manifold encoding branch connectivity along with geometry features describing the target surface. After training, the RvNN latent space can be sampled to generate new vessel geometries. By leveraging the power of generative neural networks, we generate 3D models of blood vessels that are both accurate and diverse, which is crucial for medical and surgical training, hemodynamic simulations, and many other purposes. These results closely resemble real data, achieving high similarity in vessel radii, length, and tortuosity across various datasets, including those with aneurysms. To the best of our knowledge, this work is the first to utilize this technique for synthesizing blood vessels.

Swedish researchers have developed two types of 3D bioprinting technology to artificially generate skin containing blood vessels. It could be a breakthrough in the quest to regenerate damaged skin. When treating severe burns and trauma, skin regeneration can be a matter of life or death. Extensive burns are usually treated by transplanting a thin layer of epidermis, the top layer of skin, from elsewhere on the body. However, this method not only leaves large scars, it also does not restore the skin to its original functional state.

Anatomical trees are critical for clinical diagnosis and treatment planning, yet their complex and diverse geometry make accurate representation a significant challenge. Motivated by the latest advances in large language models, we introduce an autoregressive method for synthesizing anatomical trees. Our approach first embeds vessel structures into a learned discrete vocabulary using a VQ-VAE architecture, then models their generation autoregressively with a GPT-2 model. This method effectively captures intricate geometries and branching patterns, enabling realistic vascular tree synthesis. Comprehensive qualitative and quantitative evaluations reveal that our technique achieves high-fidelity tree reconstruction with compact discrete representations. Moreover, our B-spline representation of vessel cross-sections preserves critical morphological details that are often overlooked in previous' methods parameterizations. To the best of our knowledge, this work is the first to generate blood vessels in an autoregressive manner. Code is available at https://github.com/LIA-DiTella/VesselGPT-MICCAI.

Retinal fundus images provide valuable insights into the human eye's interior structure and crucial features, such as blood vessels, optic disk, macula, and fovea. However, accurate segmentation of retinal blood vessels can be challenging due to imbalanced data distribution and varying vessel thickness. In this paper, we propose BLCB-CNN, a novel pipeline based on deep learning and bi-level class balancing scheme to achieve vessel segmentation in retinal fundus images. The BLCB-CNN scheme uses a Convolutional Neural Network (CNN) architecture and an empirical approach to balance the distribution of pixels across vessel and non-vessel classes and within thin and thick vessels. Level-I is used for vessel/non-vessel balancing and Level-II is used for thick/thin vessel balancing. Additionally, pre-processing of the input retinal fundus image is performed by Global Contrast Normalization (GCN), Contrast Limited Adaptive Histogram Equalization (CLAHE), and gamma corrections to increase intensity uniformity as well as to enhance the contrast between vessels and background pixels. The resulting balanced dataset is used for classification-based segmentation of the retinal vascular tree. We evaluate the proposed scheme on standard retinal fundus images and achieve superior performance measures, including an area under the ROC curve of 98.23%, Accuracy of 96.22%, Sensitivity of 81.57%, and Specificity of 97.65%. We also demonstrate the method's efficacy through external cross-validation on STARE images, confirming its generalization ability.

Microplastics are everywhere, both across nature and inside our bodies. And while evidence shows these synthetic particulates aren't great for you, the medical community still isn't entirely sure how the plastic specifically affects health, as well as its influence on preexisting conditions like an increased risk of heart attack or stroke. For the first time, however, experts succeeded in visually tracking the movement of microplastics through brain blood vessels in mice--and the pile-ups resembled a microscopic "car crash." The findings, published in the journal Science Advances by a team at Beijing's Peking University, expand on existing research already showcasing microplastic's potential neurotoxicity. "Nanoscale plastics can breach the blood-brain barrier, [but] how [microplastics] cause brain functional irregularities remains unclear," wrote the study's authors.

A potential Retinal Vein Occlusion (RVO) treatment involves Retinal Vein Cannulation (RVC), which requires the surgeon to insert a microneedle into the affected retinal vein and administer a clot-dissolving drug. This procedure presents significant challenges due to human physiological limitations, such as hand tremors, prolonged tool-holding periods, and constraints in depth perception using a microscope. This study proposes a robot-assisted workflow for RVC to overcome these limitations. The test robot is operated through a keyboard. An intraoperative Optical Coherence Tomography (iOCT) system is used to verify successful venous puncture before infusion. The workflow is validated using 12 ex vivo porcine eyes. These early results demonstrate a successful rate of 10 out of 12 cannulations (83.33%), affirming the feasibility of the proposed workflow.

Diabetic Retinopathy is one of the most familiar diseases and is a diabetes complication that affects eyes. Initially, diabetic retinopathy may cause no symptoms or only mild vision problems. Eventually, it can cause blindness. So early detection of symptoms could help to avoid blindness. In this paper, we present some experiments on some features of diabetic retinopathy, like properties of exudates, properties of blood vessels and properties of microaneurysm. Using the features, we can classify healthy, mild non-proliferative, moderate non-proliferative, severe non-proliferative and proliferative stages of DR. Support Vector Machine, Random Forest and Naive Bayes classifiers are used to classify the stages. Finally, Random Forest is found to be the best for higher accuracy, sensitivity and specificity of 76.5%, 77.2% and 93.3% respectively.

Fundus images are widely used for diagnosing various eye diseases, such as diabetic retinopathy, glaucoma, and age-related macular degeneration. However, manual analysis of fundus images is time-consuming and prone to errors. In this report, we propose a novel method for fundus detection using object detection and machine learning classification techniques. We use a YOLO_V8 to perform object detection on fundus images and locate the regions of interest (ROIs) such as optic disc, optic cup and lesions. We then use machine learning SVM classification algorithms to classify the ROIs into different DR stages based on the presence or absence of pathological signs such as exudates, microaneurysms, and haemorrhages etc. Our method achieves 84% accuracy and efficiency for fundus detection and can be applied for retinal fundus disease triage, especially in remote areas around the world.